Safety and side effects
When taken at appropriate doses, oral use of vitamin E is generally considered safe. Rarely, oral use of vitamin E can cause:
Increased concentration of creatine in the urine (creatinuria)
- Taking higher doses of vitamin E might increase the risk of side effects. Also, there is concern that people in poor health who take high doses of vitamin E are at increased risk of death.
Use of vitamin E can interact with many conditions. For example, research suggests that oral use of vitamin E might increase the risk of prostate cancer. Other research suggests that vitamin E use might increase the risk of death in people with a severe history of heart disease, such as heart attack or stroke. Talk with your doctor before taking vitamin E if you have:
A vitamin K deficiency
An eye condition in which the retina is damaged (retinitis pigmentosa)
A history of a previous heart attack or stroke
Head and neck cancer
The supplement might increase your risk of bleeding. If you’re planning to have surgery, stop taking vitamin E two weeks beforehand. Also, talk to your doctor about vitamin E use if you’re about to have or you just had a procedure to open blocked arteries and restore normal blood flow to your heart muscle (angioplasty).